A case report on BPDCN: Blastic Plasmacytoid Dendritic Cell Neoplasm

Dendritic cells are present in both lymphoid and non-lymphoid organs, which heterogenous group of nonphagocytic nonlymphoid immune accessory cells. Plasmacytoid dendritic cell (which has an eccentric nuclei) subset aid secreting high levels type 1 interferons by activation gaining like morphology, play important role antiviral immunity involved initiation development stages inflammatory response. The initial presentation extra-cutaneous region is involvement regional lymph nodes later progressed to bone marrow peripheral blood. When extensively involved, neoplastic interfere blood resembling as circulating leukemic myeloid or blasts. BPDCN confused with cutaneous T-cell lymphoma due involvement. Comparative adults, children less aggressive. Intensive 1st line therapy along “Lymphoid type” chemotherapy show better results. Lymphodenopathy, splenomegaly, cytopenia, lesions observed widely.